Does Semaglutide have an impact on non-diabetic individuals with overweight or obesity?

Unlocking Cardiovascular Benefits: Semaglutide's Impact on Non-Diabetic Individuals with Overweight or Obesity

In a groundbreaking study known as the SELECT Trial, researchers, led by Michael Lincoff, Kirstine Brown-Frandsen, and Helen M Colhoun, delved into the potential cardiovascular benefits of semaglutide, a glucagon-like peptide-1 receptor agonist.

Unlike previous investigations that focused on diabetic patients, this trial set out to unravel the impact of once-weekly subcutaneous semaglutide at a dosage of 2.4 mg on individuals aged 45 or older, with a body mass index (BMI) of 27 or greater and preexisting cardiovascular disease but no history of diabetes.

The findings were striking, revealing a substantial 20% reduction in the primary cardiovascular endpoint – a composite of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke – in the semaglutide group compared to the placebo group over a mean follow-up of 39.8 months.

This breakthrough discovery may reshape cardiovascular risk management strategies, especially for non-diabetic individuals grappling with overweight or obesity and preexisting cardiovascular conditions.

However, it is essential to tread cautiously, considering the higher incidence of adverse events leading to permanent discontinuation of the trial product in the semaglutide group compared to the placebo group (16.6% vs. 8.2%).

While these results are promising, the study's safety considerations underline the need for further research to comprehensively understand the long-term implications of semaglutide in this context.

The SELECT Trial, funded by Novo Nordisk (ClinicalTrials.gov number, NCT03574597), marks a pivotal step forward in uncovering new avenues for cardiovascular risk reduction beyond the diabetic spectrum.

Source: The SELECT Trial – because we love giving you the backstage pass to the scientific wonders!


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